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For more than 40 years, apoaequorin has been used to study how calcium works inside cells. Most importantly, Apoaequorin has also been proven to work in clinical studies. Quincy Bioscience frequently cites this study performed in 2014. That study was a double-blind, placebo-controlled study designed specifically to assess the effectiveness of Apoaequorin as a memory boosting supplement compared to a placebo.
Maybe so, in cell cultures in the lab. However, if this protein is ingested in a pill form, for any hope of efficacy it would have to survive digestion, be absorbed into the bloodstream, and then cross the blood brain barrier. In these studies they deemed that Apoaequorin was safe to use. However, they also use these studies to massively promote their own product, with results that no other independent study has been able to replicate. Studies have indicated improved energy in the way the mind functions during studies carried out on animals. Through modern research, we are finding out more about this protein and the results will give added benefits of using Apoaequorin as a booster and supplement. 2015-02-19 · These clinical studies, the lawsuit states, “if they exist at all, are, on their face, so seriously flawed that they demonstrate nothing regarding Prevagen.” When the FDA came knocking The FDA sent Underwood a warning letter in 2012 over the alleged illegal marketing of Prevagen as a drug without the agency’s approval.
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That study was a double-blind, placebo-controlled study designed specifically to assess the effectiveness of Apoaequorin as a memory boosting supplement compared to a placebo. Outside of company studies put together by Quincy Bioscience, there’s no real research on Apoaequorin – which doesn’t bode well for it’s overall effectiveness. Even some of the researchers in the study have mentioned that there are no statistically significant changes from those who are supplementing Apoaequorin.
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2018-02-08 · One study, authored by one of the founders of Quincy Bioscience, directly states that apoaequorin is broken down in the digestive tract. Due to this, apoaequorin cannot enter the bloodstream in an unaltered form: "Apoaequorin is easily digested by pepsin, a characteristic commonly exhibited by many non-allergenic dietary proteins. 2013-11-11 · The apoaequorin component (AQ) contains the EF-hands that bind Ca 2+ and thus was the component used in the current studies. Rats were given an infusion of AQ in zero Ca 2+ artificial cerebral spinal fluid (aCSF; in mM: 124.00 NaCl, 2.80 KCl, 2.00 MgSO 4 , 1.25 NaH 2 PO 4 , 26.00 NaHCO 3 , 10.00 D-glucose, and 0.40 Na-ascorbate), which also contained 6% DMSO to facilitate neuronal uptake of AQ. Apoaequorin has previously demonstrated the ability to reduce calcium related neuronal cell death in vitro. Qualitative in vivo studies examining the effect of apoaequorin have shown improvements in cognitive functioning and participant reported quality of life. Methods: A double-blinded, placebo controlled study of apoaequorin in 222 healthy This has spawned the idea that apoaequorin can protect nerve cells from some of the consequences of aging.
In this sense, it represents a novel approach for preventing age-related cognitive decline. Improved Recall
Given the absence of human safety studies, this apparent memory decline would raise alarms if the apoaequorin protein, which is the active ingredient in Prevagen, were able to not only survive the digestive system without being digested (which is iffy), but also cross the blood-brain barrier. It was pretty hard to find any studies on Apoaequorin but we did find this one on Pubmed. The study says there was a “strong relationship between apoaequorin and improvements on a quantitative measure of cognitive function”. When we look a little further at the study we find it was done by Kenneth Lerner and others.
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Qualitative in vivo studies examining the effect of apoaequorin have shown improvements in cognitive functioning and participant reported quality of life. Methods: A double-blinded, placebo controlled study of apoaequorin in 222 healthy This has spawned the idea that apoaequorin can protect nerve cells from some of the consequences of aging. Maybe so, in cell cultures in the lab. However, if this protein is ingested in a pill form, for any hope of efficacy it would have to survive digestion, be absorbed into the bloodstream, and then cross the blood brain barrier. In these studies they deemed that Apoaequorin was safe to use. However, they also use these studies to massively promote their own product, with results that no other independent study has been able to replicate.
A low incidence of adverse events such as headache, nausea, constipation, edema and hypertension has been reported by the makers of Prevagen (FDA GRAS Notification 2014). The FTC, in its complaint, says this is not nearly good enough and goes on to argue that Quincy’s claims that Prevagen improves memory “rely on the theory that the product’s dietary protein, apoaequorin, enters the human brain,” but that the company does not have “studies showing that orally-administered apoaequorin can cross the human blood-brain barrier.” (In their respective
Apoaequorin – Apoaequorin is a type of photoprotein that binds with calcium. This means that when held under light, this protein glows. It is found in luminescent jellyfish. Apoaequorin has an interesting calcium structure that may help the human brain regulate calcium as it ages. 2016-03-24 · Apoaequorin is claimed in this case to improve cognitive function, especially in older adults (This probably explains the ads on CNBC).
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The apoaequorin group showed a statistically significant 10-16% improvement (p<0.001) in verbal learning and working memory at the end of the 90 days, while the control group showed a more modest (3-8%) change that was not significant (p>0.2). The unique ingredient in Prevagen, apoaequorin, was evaluated for safety using a toxicity study, a common method for evaluating dietary supplements. Apoaequorin has been found to be safely consumed in doses much higher than recommended dosage (4,000 times the recommended daily amount of Prevagen Regular Strength). View The Summary Apoaequorin is a protein that comes from a specific type of jellyfish that glows. When apoaequorin is exposed to calcium, the protein and calciumbind and a blue light is produced.
Objective: The study was designed to assess the effects of a supplement of apoaequorin on verbal learning and working memory. apoaequorin makes it unlikely to reach the brain [3; 4]. SAFETY Rated 3/4 Widespread consumer use and a 90-day randomized controlled trial in older adults suggest that apoaequorin supplements are well-tolerated [5]. Safety has not been carefully evaluated for higher doses, longer periods of treatment, or for vulnerable patients who have existing
Apoaequorin, a calcium-binding protein originally isolated from jellyfish is available commercially as a dietary supplement. The objective of the present study was to investigate potential adverse effects, if any, of Apoaequorin, a recombinant protein preparation, in rats following subchronic administration. With an ingredient originally found in jellyfish! Healthier brain, better life!”.
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ALS Untangled Series: Ep. 39 - Apoaequorin Prevagen – CReATe
The objective of the present study was to investigate potential adverse effects, if any, of Apoaequorin, a recombinant protein preparation, in rats following subchronic administration.
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Common side effects include headache, dizziness, and nausea. There is not enough research assessing the safety of apoaequorin in pregnant women or nursing baby. If you are pregnant or breastfeeding, it is best to avoid this supplement. Apoaequorin has been shown in laboratory studies to support neuronal cells. Based on in vitro and in vivo animal studies, we hypothesized that apoaequorin has the potential to enhance memory and cognitive function in humans. Previous work with apoaequorin in aged canines demonstrated cognitive enhancement. This has spawned the idea that apoaequorin can protect nerve cells from some of the consequences of aging.
Based on in vitro and in vivo animal studies, we hypothesized that apoaequorin has the potential to enhance memory and cognitive function in humans. Previous work with apoaequorin in aged canines demonstrated cognitive enhancement. This has spawned the idea that apoaequorin can protect nerve cells from some of the consequences of aging. Maybe so, in cell cultures in the lab. However, if this protein is ingested in a pill form, for any hope of efficacy it would have to survive digestion, be absorbed into the bloodstream, and then cross the blood brain barrier.